Methanol → HCID 66956185, compound

Participants

Reaction Steps

To a cold (0° C.) solution of 2-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)pentanoic acid (4.24 g; 18.74 mmol) was added thionyl chloride (27.27 mL; 374.84 mmol) dropwise in methanol (70 mL). The mixture was refluxed for 48 h and then concentrated under reduced pressure to give 3.46 g (77%) of the title compound as an oil.

Provenance & Evidence