Sodium Hydroxide → HCID 50995370, compound

Participants

Reaction Conditions

Reaction Steps

A solution of sodium hydroxide 5N (1 mL) was added to a mixture of methyl 2-(2-(3-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate (0.026 g; 0.053 mmol) in methanol (1 mL). The mixture was heated in a sealed tube at 100° C. for 18 h and then concentrated under reduced pressure. The residue was dissolved in water and the pH of the solution was adjusted between 2 and 3 by addition of a solution of hydrochloric acid 6N. The precipitate was collected by filtration and dried under reduced pressure over phosphorus pentoxide to give 0.084 g (33%) of the title compound as a white solid.

Provenance & Evidence