Sodium Hydroxide → HCID 50995183, compound

Participants

Reaction Conditions

Reaction Steps

A solution of sodium hydroxide 5N (1 mL) was added to a mixture of methyl 2-(4-methyl-2-(3-phenoxypiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate (0.050 g; 0.053 mmol) in methanol (1 mL). The mixture was heated in a sealed tube at 100° C. for 18 h and then concentrated under reduced pressure. The residue was dissolved in water and the pH of the solution was adjusted between 2 and 3 by addition of a solution of hydrochloric acid 6N. The aqueous layer was extracted with ethyl acetate, dried and concentrated under reduced pressure. Purification by preparative HPLC (HPLC method 4) furnished 0.013 g (26%) of the title compound as a white solid.

Provenance & Evidence