Sodium Hydroxide → HCID 50995181, compound

Participants

Reaction Conditions

Reaction Steps

A solution of sodium hydroxide 5N (0.5 mL) was added to a mixture of methyl 2-(4-methyl-2-(3-phenylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate (0.047 g; 0.103 mmol) in methanol (1.5 mL). The mixture was heated in a sealed tube at 100° C. for 18 h and then concentrated under reduced pressure. The residue was dissolved in water and the pH of the solution was adjusted between 3 and 4 by addition of a solution of hydrochloric acid 6N. The aqueous layer was extracted with ethyl acetate, dried over sodium sulphate, filtered and concentrated under reduced pressure. Purification by preparative HPLC (HPLC method 4) furnished 0.014 g (31%) of the title compound as a white solid.

Provenance & Evidence