Sodium Hydroxide → HCID 66955947, compound

Participants

Reaction Conditions

Reaction Steps

A solution of sodium hydroxide 5N (0.5 mL) was added to a mixture of methyl 2-(2-(indolin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate (0.040 g; 0.096 mmol) in methanol (1.5 mL). The mixture was heated in a sealed tube at 100° C. for 18 h and then concentrated under reduced pressure. The residue was dissolved in water and the pH of the solution was adjusted between 3 and 4 by addition of a solution of hydrochloric acid 6N. The precipitate was collected by filtration, dried under reduced pressure over phosphorous pentoxide and purified by preparative HPLC (HPLC method 5) furnished 0.010 g (25%) of the title compound as a white solid.

Provenance & Evidence