Sodium Hydroxide → HCID 66955193, compound

HRID 1399643Notes

Reaction equation

HRID 1399643 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[C:11]1[C:16]([CH:17]([CH2:22][CH2:23][CH3:24])[C:18]([O:20]C)=[O:19])=[C:15]([CH3:25])[N:14]=[C:13]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:12]=1.[OH-].[Na+]>CO>[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[C:11]1[C:16]([CH:17]([CH2:22][CH2:23][CH3:24])[C:18]([OH:20])=[O:19])=[C:15]([CH3:25])[N:14]=[C:13]([C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[N:12]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66955330HCID 66955330, compound

Product 1

HCID 66955193HCID 66955193, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-(3,4-dihydroisoquinolin-2(1H)-yl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoate (0.110 g; 0.265 mmol), sodium hydroxide 10N (0.265 mL; 2.65 mmol) in methanol (2.6 mL) to afford 0.073 g (69%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-c17fda7240cb4c8aba254f3e48630b92
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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