Sodium Hydroxide → HCID 66955987, compound

HRID 1399647Notes

Reaction equation

HRID 1399647 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]3[C:15]([CH:16]([CH2:21][CH2:22][CH3:23])[C:17]([O:19]C)=[O:18])=[C:14]([CH3:24])[N:13]=[C:12]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[N:11]=3)=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[OH-].[Na+]>CO>[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]3[C:15]([CH:16]([CH2:21][CH2:22][CH3:23])[C:17]([OH:19])=[O:18])=[C:14]([CH3:24])[N:13]=[C:12]([C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=4)[N:11]=3)=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66955905HCID 66955905, compound

Product 1

HCID 66955987HCID 66955987, compoundYield 49.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-(1H-indol-5-yl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoate (0.098 g; 0.245 mmol), sodium hydroxide 10N (0.245 mL; 2.45 mmol) in methanol (2.5 mL) to afford 0.047 g (48%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-717e6c81a23f4f96bfafecb776b45370
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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