Sodium Hydroxide → HCID 66955817, compound

HRID 1399661Notes

Reaction equation

HRID 1399661 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([CH:14]([CH2:19][CH2:20][CH3:21])[C:15]([O:17]C)=[O:16])=[C:12]([CH3:22])[N:11]=[C:10]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:9]=2)=[C:4]([F:29])[CH:3]=1.[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([CH:14]([CH2:19][CH2:20][CH3:21])[C:15]([OH:17])=[O:16])=[C:12]([CH3:22])[N:11]=[C:10]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[N:9]=2)=[C:4]([F:29])[CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66955308HCID 66955308, compound

Product 1

HCID 66955817HCID 66955817, compoundYield 51.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-(4-chloro-2-fluorophenyl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoate (0.164 g; 0.397 mmol), sodium hydroxide 10N (0.397 mL; 3.97 mmol) in methanol (4 mL) to afford 0.082 g (49%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-0004298751a64cc68d7b0b4f8ec1e327
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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