Sodium Hydroxide → HCID 66955581, compound

HRID 1399665Notes

Reaction equation

HRID 1399665 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:14]([CH:15]([CH2:20][CH2:21][CH3:22])[C:16]([O:18]C)=[O:17])=[C:13]([CH3:23])[N:12]=[C:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[N:10]=1.[OH-].[Na+]>CO>[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:14]([CH:15]([CH2:20][CH2:21][CH3:22])[C:16]([OH:18])=[O:17])=[C:13]([CH3:23])[N:12]=[C:11]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[N:10]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66955334HCID 66955334, compound

Product 1

HCID 66955581HCID 66955581, compoundYield 86.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-(2-fluoro-4-methylphenyl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoate (0.067 g; 0.171 mmol), sodium hydroxide 10N (0.171 mL; 1.71 mmol) in methanol (1.7 mL) to afford 0.056 g (86%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-16b952d455b34078a8ce614204c925f4
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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