4-Chlorophenylboronic acid → HCID 66955365, compound

Participants

Reaction Steps

This compound was prepared according to general method E from methyl 2-(4-chloro-6-methyl-2-phenylpyrimidin-5-yl)pentanoate (0.08 g; 0.25 mmol), tetrakis(triphenylphosphine) palladium(0) (0.029 mg; 0.025 mmol), N,N-diisopropylethylamine (0.173 mL; 1 mmol) and 4-chlorophenylboronic acid (0.058 g; 0.37 mmol) in DME-water (1 mL) for 2.5 h. Purification by flash-chromatography on silica gel using a gradient of ethyl acetate (2-20%) in heptane furnished 0.056 g (51%) of the title compound.

Provenance & Evidence