Sodium Hydroxide → HCID 66955893, compound

HRID 1399675Notes

Reaction equation

HRID 1399675 reaction equation
[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([O:11]C)=[O:10])=[C:6]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=2)[N:5]=[C:4]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:3]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([OH:11])=[O:10])=[C:6]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:24])([F:23])[F:25])=[CH:18][CH:17]=2)[N:5]=[C:4]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66955686HCID 66955686, compound

Product 1

HCID 66955893HCID 66955893, compoundYield 98.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-methyl-2-phenyl-6-(4-(trifluoromethyl)phenyl)pyrimidin-5-yl)pentanoate (0.061 g; 0.142 mmol), sodium hydroxide 10N (0.200 mL; 2.0 mmol) in methanol (2 mL) to afford 0.058 g (98%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-1c065aecae994df1a674ac4d6eb883fa
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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