Lithium iodide → 2-(4-(Benzo[d]thiazol-6-yl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoic acid

Participants

Reaction Conditions

Reaction Steps

Methyl 2-(4-(benzo[d]thiazol-6-yl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoate (0.041 g; 0.098 mmol) and lithium iodide (0.039 mg; 0.295 mmol) were placed in a microwave vial and dissolved in pyridine (0.7 mL). The vial was purged with nitrogen and heated to 125° C. for 48 h. The solvent was removed under reduced pressure, the residue was dissolved in water and the pH of the solution was adjusted between 2 and 3 by addition of a solution of hydrochloric acid 6N until a precipitate formed. The precipitate was collected by filtration and dried under reduced pressure over phosphorus pentoxide. Purification by flash-chromatography on silica gel using a gradient of methanol (1-10%) in dichloromethane furnished 0.015 g (35%) of the title compound as a brown solid.

Provenance & Evidence