Sodium Hydroxide → 2-(4-(4-Isopropylphenyl)-6-methyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoic acid

HRID 1399704Notes

Reaction equation

HRID 1399704 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:15]([CH:16]([CH2:21][CH2:22][CH3:23])[C:17]([O:19]C)=[O:18])=[C:14]([CH3:24])[N:13]=[C:12]([N:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[N:11]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[OH-].[Na+]>CO>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:15]([CH:16]([CH2:21][CH2:22][CH3:23])[C:17]([OH:19])=[O:18])=[C:14]([CH3:24])[N:13]=[C:12]([N:25]3[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]3)[N:11]=2)=[CH:6][CH:5]=1)([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 50995729Methyl 2-(4-(4-isopropylphenyl)-6-methyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate

Product 1

HCID 509955502-(4-(4-Isopropylphenyl)-6-methyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoic acidYield 75.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-(4-isopropylphenyl)-6-methyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate (0.074 g; 0.181 mmol), sodium hydroxide 10N (0.200 mL; 2.00 mmol) in methanol (2 mL) at 60° C. for 18 h furnished 0.054 g (73%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-f66426d040b040d9a5de08bffc730e10
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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