反应详情

This compound was prepared according to general method D from methyl 2-(4-methyl-2-(piperidin-1-yl)-6-(quinolin-8-yl)pyrimidin-5-yl)pentanoate (0.057 g; 0.136 mmol), sodium hydroxide 10N solution (0.200 mL; 2.00 mmol) in methanol (2 mL) at 60° C. for 18 h. Purification by flash-chromatography on silica gel using a gradient of methanol (1-10%) in dichloromethane, followed by a purification by preperative HPLC (HPLC method 1) furnished 0.0059 g (9%) of the title compound.

1. customThis compound was prepared
2. customPurification by flash-chromatography on silica gel using a gradient of methanol (1-10%) in dichloromethane
3. customfollowed by a purification by preperative HPLC (HPLC method 1)