Sodium Hydroxide → HCID 50997319, compound

Participants

Reaction Steps

This compound was prepared according to general method D from methyl 2-(4-methyl-2,6-di(piperidin-1-yl)pyrimidin-5-yl)pentanoate (0.042 g; 0.112 mmol), sodium hydroxide 10N (0.150 mL; 1.50 mmol) in methanol (2 mL) at 60° C. for 18 h. Purification by flash-chromatography on silica gel using a gradient of methanol (1-10%) in dichloromethane, followed by a purification by preparative HPLC (HPLC method 2) furnished 0.013 g (31%) of the title compound as a white solid.

Provenance & Evidence