Cornforth reagent → HCID 86665654, compound

Participants

Reaction Steps

To a solution of (4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)methanol (0.800 g; 2,69 mmol) in dichloromethane (27 mL) was added molecular sieves (4 Å) and pyridinium dichromate (1,52 g; 4,04 mmol). The reaction was stirred at room temperature for 21 h. An excess of celite was added to the reaction and the suspension was stirred for 30 min, filtered on a plug of celite and concentrated under reduced pressure. Purification by flash-chromatography on silica gel using a gradient of ethyl acetate (2-20%) in heptane furnished 0.487 g (61%) of the desired compound as a white solid.

Provenance & Evidence