Sodium Hydroxide → HCID 66956120, compound

Participants

Reaction Steps

To a mixture of methyl 2-tert-butoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate (0.030 g; 0.073 mmol) in a mixture dichloromethane-methanol (10:1) (0.55 ml) was added a solution of sodium hydroxide (2N in methanol) (0.075 ml; 0.150 mmol) and the reaction was stirred at room temperature for 24 h. The solvent was removed under reduced pressure, the residue diluted with water and washed with diethyl ether. The pH of the aqueous layer was adjusted to 2 with a solution of hydrochloric acid 2N and the suspension was extracted twice with dichloromethane. The combined organic layers were dried over sodium sulphate, filtered and concentrated under reduced pressure to furnish 0.020 g (65%) of the title compound as a white solid.

Provenance & Evidence