HCID 89647619, compound → HCID 89647472, compound

Participants

Reaction Steps

A mixture of 6-morpholino-N-(naphthalen-1-ylmethyl)-3-nitropyridin-2-amine (3.56 g, 9.78 mmol) and 10% Pd/C (300 mg) in MeOH (200 mL) was stirred at room temperature for 3 h under a balloon pressure of H2. It was filtered and the filtrate was concentrated in vacuo to afford the desired as a dark-green solid (3.2 g, 98%); LC/MS: MS (ES+) m/e 335 (MH+); 1H NMR (300 MHz, DMSO-d6) δ ppm 3.10 (t, J=4.5 Hz, 4H), 3.60 (t, J=4.5 Hz, 4H), 4.11 (s, 2H), 4.98 (d, J=5.4 Hz, 2H), 5.79 (d, J=8.1 Hz, 1H), 5.97 (t, J=5.4 Hz, 1H), 6.71 (d, J=8.1 Hz, 1H), 7.42-7.53 (m, 4H), 7.81 (d, J=7.5 Hz, 1H), 7.93 (t, J=4.8 Hz, 1H), 8.21 (d, J=4.8 Hz, 1H).

Provenance & Evidence