Acetyl chloride → HCID 86729288, compound

HRID 1399892Notes

Reaction equation

HRID 1399892 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[CH:8][N:7]([CH:10]3[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]3)[C:6]=2[CH:16]=1.[C:17](Cl)([CH3:19])=[O:18]>C(Cl)Cl.N1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[CH:8][N:7]([CH:10]3[CH2:11][CH2:12][N:13]([C:17](=[O:18])[CH3:19])[CH2:14][CH2:15]3)[C:6]=2[CH:16]=1

Participants

5

Reactant 2

HCID 6367Acetyl chlorideHCID 84811841HCID 84811841, compound

Product 1

HCID 86729288HCID 86729288, compound

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 6-bromo-1-(piperidin-4-yl)-1H-benzo[d]imidazole (50 mg, 0.178 mmol) in DCM (5 mL) in pyridine (5 mL) cooled by an ice-bath was added AcCl (14 mg, 0.178 mmol). The reaction mixture was stirred at room temperature for 3 h. The solvents were removed by concentration and the residue used for next step without further purification.

Workup

  1. customThe solvents were removed by concentration
  2. customthe residue used for next step without further purification

Sources & evidence

ORD record
ord-cf1a0014407f491cbb3c5d1e9edb08a6
Source dataset
uspto-grants-2014_12
Patent number
US08906900B2

Reaction notes

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