5-Bromo-2-chloropyrimidine → Pyrimidine, 5-bromo-2-methoxy-

HRID 1399940Notes

Reaction equation

HRID 1399940 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5](Cl)=[N:6][CH:7]=1.[CH3:9][O-:10].[Na+]>CO>[Br:1][C:2]1[CH:3]=[N:4][C:5]([O:10][CH3:9])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 6066655-Bromo-2-chloropyrimidineHCID 10942334Sodium Methoxide

Product 1

HCID 139657Pyrimidine, 5-bromo-2-methoxy-

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-Bromo-2-chloropyrimidine (10 g, 52 mmol) and sodium methoxide (8.42 g, 156 mmol) were taken in methanol (50 mL) and stirred at room temperature overnight. Reaction mixture was concentrated followed by the addition of water. The resulting mixture was extracted with ethyl acetate and dried over MgSO4. The titled compound was obtained after concentration (8.07 g, 82.5%).

Workup

  1. customReaction mixture
  2. concentrationwas concentrated
  3. additionfollowed by the addition of water
  4. extractionThe resulting mixture was extracted with ethyl acetate
  5. dry with materialdried over MgSO4

Sources & evidence

ORD record
ord-e56452663604409ea68f24496e95423e
Source dataset
uspto-grants-2014_12
Patent number
US08906909B2

Reaction notes

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