Potassium Hydroxide → HCID 89807054, compound

Participants

Reaction Steps

To an ice-cold solution of ii (3.0 g, 11.95 mmol) in DMSO (10 mL) was added KOH (1.0 g, 17.92 mmol) followed by the addition of (S)-3-fluoropyrrolidine hydrochloride (2.2 g, 17.92 mmol) under inert atmosphere. The mixture was stirred at 0° C. to RT for 20 min. The mixture was diluted with ice cold H2O followed by extraction with EtOAc (3×150 mL). The combined organic layers were washed with brine, dried (Na2SO4) and evaporated in vacuo to give Precursor 44 (3.0 g, 96%).

Provenance & Evidence