反应详情

To an ice-cold solution of 1-(2-chloro-4-pyridyl)ethanone (1.0 g, 6.42 mmol) in MeOH was added NaBH4 (0.73 g, 19.21 mmol) and the solution stirred at RT for 30 min. The reaction was then quenched with saturated NH4Cl solution followed by extraction with EtOAc (3×100 mL). The combined organic layers were washed with brine, dried (Na2SO4) and evaporated in vacuo to obtain i (0.61 g, 60%). MS 158.10 [M+H]+.

1. customThe reaction was then quenched with saturated NH4Cl solution
2. extractionfollowed by extraction with EtOAc (3×100 mL)
3. washThe combined organic layers were washed with brine
4. dry with materialdried (Na2SO4)
5. customevaporated in vacuo
6. customto obtain i (0.61 g, 60%)