Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1-(5-Chloropyrazin-2-yl)ethan-1-one | HCID 44828689 | — |
| Reactant | HCID 71726538 | HCID 71726538 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86696903 | HCID 86696903 | — |
Reaction Steps
Intermediate 1 (171 mg, 0.5 mmol), 1-(5-chloropyrazin-2-yl)ethanone (94 mg, 0.60 mmol) and PdCl2(dppf) (41 mg, 0.05 mmol) were suspended in 1,4-dioxane (8 mL). A solution of Cs2CO3 (488 mg, 1.50 mmol) in H2O (2 mL) was added. The mixture was then heated under microwave irradiation at 100° C. for 30 min. The mixture was filtered, washed with H2O, EtOH, MeOH and Et2O to afford i (172 mg, 82%). MS: 419.06 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08906902B2 |
|---|
| Source dataset | uspto-grants-2014_12 |
|---|
| ORD ID | ord-a0bd37ef719e4936afecb897603b1757 |
|---|
| Source note | uspto-grants-2014_12 |
|---|
