Cesium carbonate → HCID 86696909, compound

Participants

Reaction Conditions

Reaction Steps

Intermediate 1 (29 mg, 0.085 mmol), ii (20 mg, 78 mmol), Cs2CO3 (55 mg 0.17 mmol) and Pd(Ph3)2Cl2 (3 mg, 4 mmol) were dissolved in 1,4-dioxane:H2O (10:1, 10 mL). The mixture was degassed with a stream of N2 for 10 min, then heated in a microwave reactor at 80° C. for 1 h. The reaction was concentrated in vacuo, re-dissolved in a minimum quantity of DCM and purified by chromatography on silica (0-10% DCM-MeOH) yielding iii (23 mg 57%). MS: 475.0, [M+H]+.

Provenance & Evidence