Diethyl Ether → HCID 71765373, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of iv (40 mg, 0.1 mmol) in THF (0.7 mL) was added bromo(methyl)magnesium 3M in Et2O (0.250 mL, 0.1 mmol) and the mixture heated at 40° C. for 1 h. NH4Cl (sat. aq.) was added and the mixture extracted with DCM:IPA (5:1). The organic layers were washed with brine and then concentrated in vacuo to give a crude product that was purified by reverse phase SP4 (ACN gradient in H2O) affording Compound 9 (1.9 mg, 4%).

Provenance & Evidence