HCID 71726538, compound → HCID 71765375, compound

Participants

Reaction Conditions

Reaction Steps

Compound i (74 mg) and Intermediate 1 (100 mg) were suspended in pyridine with 4 Å mol. sieves. The mixture was degassed and flushed with oxygen and Cu(OAc)2.H2O added. The mixture was again degassed and flushed with oxygen then left stirring at 80° C. for 280 min. The reaction was quenched by adding NH4Cl sat. and diluted with EtOAc and H2O. The mixture was extracted with EtOAc and the organics combined, dried (Na2SO4) and evaporated to dryness. Purification by chromatography on silica, eluting with DCM/MeOH (0-10%) followed by reverse phase chromatography on a C18 column eluting with ACN/H2O afforded Compound 11 (7.5 mg).

Provenance & Evidence