1,2-Dichloroethane → HCID 49853916, compound

Participants

Reaction Steps

To a stirred solution of hydrochloride salt of N-{3-[4-(3-aza-bicyclo[3.1.0]hex-1-yl)-phenyl]-2-oxo-oxazolidin-5(S)-yl-methyl}-acetamide (Intermediate IV) (163 mg, 0.46 mmol), in DMF (20 mL), were added α-oxo-2-furanacetic acid (65 mg, 0.46 mmol), EDC (97 mg, 0.51 mmol), HOBt (69 mg, 0.51 mmol) and NMM (0.11 mL, 1.02 mmol) at 0° C. The reaction mixture was stirred at r.t. and progress of the reaction was monitored by TLC. On completion, DMF was evaporated in vacuo and residue was dissolved in chloroform (50 mL). The organic layer was washed with water (25 mL), brine (25 mL), dried over anhydrous sodium sulphate and concentrated in vacuo. The residue was purified by column chromatography (silica gel, 0.4:9.6 MeOH:CHCl3) to provide the title compound (140 mg, 69%) as white solid.

Provenance & Evidence