Methyl chloroformate → HCID 67508140, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of solution of compound (400 mg, 1.1 mmol) obtained in Step 1, in THF (20 mL) was added triethylamine (0.45 mL, 3.2 mmol). The resulting solution was cooled to 0° C. and methyl chloroformate (0.12 mL, 1.6 mmol) was added dropwise. The reaction mixture was stirred at r.t. and progress of the reaction was monitored by TLC. On completion, the reaction mixture was diluted with DCM (60 mL). The organic layer was washed with water (25 mL), brine (25 mL), dried over anhydrous sodium sulphate and concentrated in vacuo. The residue was purified by column chromatography (silica gel, 2:8 EtOAc:Pet. ether) to provide the title compound (320 mg, 70%) as white solid.

Provenance & Evidence