2-Pyrrolidone → HCID 67517904, compound

HRID 1400058Notes

Reaction equation

HRID 1400058 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:27]=[CH:28][C:29]=1[Cl:30])[O:5][CH2:6][CH:7]1[C:12]2([C:13]3[CH:18]=[CH:17][C:16](Br)=[CH:15][CH:14]=3)[CH:8]1[CH2:9][N:10]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:11]2.[NH:31]1[CH2:35][CH2:34][CH2:33][C:32]1=[O:36]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:27]=[CH:28][C:29]=1[Cl:30])[O:5][CH2:6][CH:7]1[C:12]2([C:13]3[CH:18]=[CH:17][C:16]([N:31]4[CH2:35][CH2:34][CH2:33][C:32]4=[O:36])=[CH:15][CH:14]=3)[CH:8]1[CH2:9][N:10]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:11]2

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 67508935HCID 67508935, compound

Product 1

HCID 67517904HCID 67517904, compound

Procedure

The title compound was prepared from tert-butyl 6-((3,4-dichlorophenoxy)methyl)-1-(4-bromophenyl)-3-aza-bicyclo[3.1.0]hexane-3-carboxylate obtained in Step 1 of Example XXXV and 2-pyrrolidinone using the method described for Step 1 (Example XXXIII)

Sources & evidence

ORD record
ord-1759f1baf8844d71844cb2ac29f551a6
Source dataset
uspto-grants-2014_12
Patent number
US08906913B2

Reaction notes

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