HCID 66764889, compound → HCID 56836074, compound

Participants

Reaction Steps

100 mg of N-(2-{2-[2-(4-methanesulfonylphenylamino)pyrimidin-4-yl]ethynyl}-phenyl)-N-methylmethanesulfonamide are dissolved in 1 ml of methanol, and 100 mg of activated carbon (with 10% of Pd) are added. A hydrogen atmosphere is generated, and the suspension is stirred at room temperature for 3 h. The catalyst is subsequently filtered off, and the solvent is removed. The residue is chromatographed on silica gel, giving 50 mg of the title compound as colourless solid;

Provenance & Evidence