6-amino-3,4-dihydroquinolin-2(1H)-one → HCID 56649303, compound

Participants

Reaction Conditions

Reaction Steps

200 mg of N-{2-[2-(2-chloropyrimidin-4-yl)ethyl]phenyl}-N-methylmethanesulfonamide and 70 mg of 6-amino-3,4-dihydroquinolin-2(1H)-one are dissolved in 3 ml of n-butanol and warmed at 120° C. for 12 h in a sealed vessel. After cooling to room temperature, the solvent is removed in vacuo, and the residue is chromatographed on silica gel, giving 50 mg of the title compound as colourless solid;

Provenance & Evidence