Water → HCID 89823611, compound

Participants

Reaction Steps

A solution of Example 11A (5.5 g, 9.8 mmol) and NaBH4 (1.1 g, 29.4 mmol) in dichloromethane/ethanol (20 mL/20 mL) was stirred at room temperature for 2 hours. Water was added and the resulting solution was adjusted to pH=10 with saturated Na2CO3 solution and extracted with ethyl acetate. The combined organic layer was washed with brine, dried over Na2SO4, filtered, and concentrated to result in the title compound (4.3 g, 95%).

Provenance & Evidence