N-bromobutanimide → HCID 178518920, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-trifluoromethyl-pyridazin-3-ol (9.0 g, 54.9 mmol) (D3) and N-bromosuccinimide (12.7 g, 71.4 mmol) in a mixture of acetic acid (15 ml) and acetonitrile (350 ml) was stirred at 60° C. for 6 h. and at room temperature for a further 16 h. After this period, the reaction mixture was diluted with dichloromethane and extracted with a 10% solution of sodium thiosulfite. The organic layer was separated, dried (MgSO4) and the solvent evaporated in vacuo to yield D4 (12.7 g, 95%) as a yellow solid. C5H2BrF3N2O requires 243; Found 244 (MH+).

Provenance & Evidence