HCID 59233383, compound → HCID 59233384, compound

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Reaction Steps

A mixture of 4-(4-Methoxy-6-trifluoromethyl-pyridazin-3-ylamino)-piperidine-1-carboxylic acid tent-butyl ester (D7) (0.73 g, 1.93 mmol) and Amberlyst® 15 ion exchange resin, acidic form (4.1 mmol/g) (2.35 g, 9.65 mmol) in methanol (20 ml) was shaken at room temperature for 18 h. After this period, the mixture was filtered and then a 7M solution of ammonia in methanol was added. The mixture was shaken for 1 h, filtered and the filtrate evaporated in vacuo. The crude product was purified by flash column chromatography (silica gel; 3% ammonia in methanol (7M)/dichloromethane). The desired fractions were collected and evaporated in vacuo. to yield D8 (0.49 g, 92%) as a yellow syrup. C11H15F3N4O requires 276; Found 277 (MH+).

Provenance & Evidence