Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isoindoline | HCID 422478 | — |
| Reactant | HCID 67154027 | HCID 67154027 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 68227310 | HCID 68227310 | 32.3% |
Reaction Steps
3.2 g of isoindoline are added to 9.3 g of 5-(1-ethoxycarbonylcyclopropyl)-1-tert-butoxycarbonyl-2,3-dioxoindoline in 100 ml of tetrahydrofuran, and the mixture is subsequently stirred at 23° C. for 1 h. The mixture is evaporated to dryness in vacuo and purified by column chromatography, giving 4.0 g (32%) of ethyl 1-[4-(tert-butoxycarbonylamino)-3-(2-isoindolin-2-yl-2-oxoacetyl)phenyl]cyclopropanecarboxylate;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08906930B2 |
|---|
| Source dataset | uspto-grants-2014_12 |
|---|
| ORD ID | ord-55b93eb8ea9242538296ff3caea16a37 |
|---|
| Source note | uspto-grants-2014_12 |
|---|
