Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isoindoline | HCID 422478 | — |
| Reactant | HCID 67154054 | HCID 67154054 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 68227402 | HCID 68227402 | 28% |
Reaction Steps
1.049 g of isoindoline are added to 3.3 g of 5-(1-ethoxycarbonylcyclobutyl)-1-tert-butoxycarbonyl-2,3-dioxoindoline in 50 ml of tetrahydrofuran, and the mixture is subsequently stirred at 23° C. for 1 h. The mixture is evaporated to dryness in vacuo and purified by column chromatography, giving 1.2 g (28%) of ethyl 1-[4-(tert-butoxycarbonylamino)-3-(2-isoindolin-2-yl-2-oxoacetyl)phenyl]cyclobutanecarboxylate; LC-MS retention time: 2.75 min (“nonpolar” gradient).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08906930B2 |
|---|
| Source dataset | uspto-grants-2014_12 |
|---|
| ORD ID | ord-165714afc7824f11b543d731226401aa |
|---|
| Source note | uspto-grants-2014_12 |
|---|
