Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isoindoline | HCID 422478 | — |
| Reactant | HCID 67154018 | HCID 67154018 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67154010 | HCID 67154010 | 25% |
Reaction Steps
1.53 g of isoindoline are added to 5.29 g of 5-(1-ethoxycarbonyl-4,4-difluorobutyl)-1-tert-butoxycarbonyl-2,3-dioxoindoline in 50 ml of tetrahydrofuran, and the mixture is subsequently stirred at 23° C. for 1 h. The mixture is evaporated to dryness in vacuo and purified by column chromatography, giving 1.7 g (25%) of ethyl 2-[4-(tert-butoxycarbonylamino)-3-(2-isoindolin-2-yl-2-oxoacetyl)phenyl]-5,5-difluoropentanoate; LC-MS retention time: 2.62 min (“nonpolar” gradient).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08906930B2 |
|---|
| Source dataset | uspto-grants-2014_12 |
|---|
| ORD ID | ord-f538251f79594564bc88f39003bb5f98 |
|---|
| Source note | uspto-grants-2014_12 |
|---|
