Hydrochloric Acid → HCID 68227263, compound

Participants

Reaction Conditions

Reaction Steps

188 mg of ethyl 2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]acetate are suspended in 1 ml of DMF, and 60 μl of 1,4-dibromobutane are added. 80 mg of sodium hydride are subsequently added with ice-cooling, and the mixture is stirred with cooling for a further 30 min. After 1 h at 23° C., the mixture is re-cooled, and a further 10 mg of sodium hydride are added to the mixture. The mixture is stirred at 23° C. for a further 30 min, 1 ml of 2N sodium hydroxide solution is added, and the mixture is stirred at 70° C. for 12 h. After cooling to 23° C., the mixture is acidified by dropwise addition of 1N hydrochloric acid, with a yellow precipitate forming. This is filtered off, washed with water and dried at 50° C. for 12 h.

Provenance & Evidence