Sodium hydride → HCID 68227620, compound

Participants

Reaction Steps

1 g of ethyl 2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]acetate are suspended in 10 ml of DMF, and 1 g of tert-butyl 3-bromo-2-(bromomethyl)propanoate is added. 324 mg of sodium hydride are subsequently added with ice-cooling, and the mixture is stirred with cooling for a further 30 min. After 1 h at 23° C., the mixture is poured into 50 ml of saturated ammonium chloride solution, with a precipitate forming. This is filtered off, washed with water and dried at 50° C. for 12 h. Yield: 900 mg (66%) of O1-tert-butyl O5-ethyl 4-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-2-methylenepentanedioate;

Provenance & Evidence