Sodium Chloride → HCID 46870680, compound

Participants

Reaction Steps

160 mg of EDC and 36 μL of 2,2-dichloroacetic acid were added to 42 mg N-(4-amino-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-2-(1H-benzo[d]imidazol-2-yl)nicotinamide (0.096 mmol) in 2 ml of dry dimethylsulfoxide (DMSO), and the reaction mixture stirred for 25 minutes at room temperature. For work up the reaction mixture was mixed with 40 ml of NaCl solution and sat. NaHCO3 (1:1) for 10 minutes. The resulting solid was filtered off with suction, washed with water and dried. 24 mg of the title compound were obtained as lightgrey amorphous solid.

Provenance & Evidence