Diisopropylethylamine → HCID 67541222, compound

Participants

Reaction Conditions

Reaction Steps

0.58 g 1-Hydroxybenzotriazole hydrate, 0.75 ml diisopropylethylamin (DIPEA) and 0.82 g EDC successively were added to a solution of 2-(1,3-benzothiazol-2-yl)benzoic acid (1.0 g, 3.90 mmol) in a mixture of 1.5 ml DMF und 20 ml THF at 5° C., and stirred at 5° C. for 1 hour. 3-Amino-2-hydroxy-4-phenylbutanamide (0.8 g, 3.9 mmol) was added, and the reaction mixture stirred for 1 hour at 5° C. and then over night at room temperature. For work up water was added under cooling, the precipitate formed filtered off with suction and dried to give 1.33 g of the title compound.

Provenance & Evidence