反应详情

温度

60 °C

3 ml of a 2N NaOH solution were added to a solution of ethyl 2-(4-(4-fluorophenyl)thiazol-2-yl)nicotinate (430 mg, 1.31 mmol) in 25 ml of methanol, and afterwards stirred for 2 hours at 60° C. The reaction mixture was subsequently evaporated to dryness, mixed with water and neutralized by adding 2N HCl. Filtration with suction and drying the precipitate formed resulted in 356 mg of the acid as yellow amorphous solid.

1. customThe reaction mixture was subsequently evaporated to dryness
2. additionmixed with water
3. additionby adding 2N HCl
4. filtrationFiltration with suction
5. customdrying the precipitate
6. customformed