3-Amino-2-hydroxy-4-phenylbutanamide → HCID 67539912, compound

HRID 1400225Notes

Reaction equation

HRID 1400225 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([C:13]3[N:21]=[CH:20][CH:19]=[CH:18][C:14]=3[C:15]([OH:17])=O)[S:11][CH:12]=2)=[CH:4][CH:3]=1.[NH2:22][CH:23]([CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH:24]([OH:28])[C:25]([NH2:27])=[O:26]>>[NH2:27][C:25](=[O:26])[CH:24]([OH:28])[CH:23]([NH:22][C:15](=[O:17])[C:14]1[CH:18]=[CH:19][CH:20]=[N:21][C:13]=1[C:10]1[S:11][CH:12]=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[N:9]=1)[CH2:29][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Participants

3

Reactant 2

HCID 138823553-Amino-2-hydroxy-4-phenylbutanamideHCID 675410702-(4-(4-Fluorophenyl)thiazol-2-yl)nicotinic acid

Product 1

HCID 67539912HCID 67539912, compoundYield 93.9%

Procedure

Coupling of 2-(4-(4-fluorophenyl)thiazol-2-yl)nicotinic acid (356 mg, 1.185 mmol) and 3-amino-2-hydroxy-4-phenylbutanamide (280 mg, 1.442 mmol) in an analogous manner as described for example 1.2 afforded 530 mg of the title compound as white amorphous solid.

Sources & evidence

ORD record
ord-4331ea1be485494dbe5c137ffe63e3ce
Source dataset
uspto-grants-2014_12
Patent number
US08906941B2

Reaction notes

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