Sodium Hydroxide → HCID 67539143, compound

HRID 1400228Notes

Reaction equation

HRID 1400228 reaction equation
[OH-].[Na+].[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[S:11][CH:12]=[C:13]([C:15]3[N:24]=[CH:23][CH:22]=[CH:21][C:16]=3[C:17]([O:19]C)=[O:18])[N:14]=2)=[CH:6][CH:5]=1>CO>[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[S:11][CH:12]=[C:13]([C:15]3[N:24]=[CH:23][CH:22]=[CH:21][C:16]=3[C:17]([OH:19])=[O:18])[N:14]=2)=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67540489HCID 67540489, compound

Product 1

HCID 67539143HCID 67539143, compoundYield 85.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

5.5 ml of a 2N NaOH solution were added to a solution of methyl 2-(2-(4-fluorophenyl)thiazol-4-yl)nicotinate (850 mg, 2.7 mmol) in 30 ml of methanol, and afterwards stirred for 4 hours at 50° C. The reaction mixture was evaporated to dryness, mixed with water and neutralized by adding 2N HCl. Filtration with suction and drying the precipitate formed resulted in 690 mg of the acid as amorphous solid.

Workup

  1. customThe reaction mixture was evaporated to dryness
  2. additionmixed with water
  3. additionby adding 2N HCl
  4. filtrationFiltration with suction
  5. customdrying the precipitate
  6. customformed

Sources & evidence

ORD record
ord-f3ff46f541ce4c3883b014ba16e5dfa9
Source dataset
uspto-grants-2014_12
Patent number
US08906941B2

Reaction notes

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