2-(2-Phenyl-1,3-thiazol-4-yl)benzoic acid → HCID 67540821, compound

HRID 1400230Notes

Reaction equation

HRID 1400230 reaction equation
[C:1]1([C:7]2[S:8][CH:9]=[C:10]([C:12]3[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=3[C:14]([OH:16])=O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl-].[NH2:22][C:23](=[O:32])[CH:24]([OH:31])[CH:25]([NH3+:30])[CH2:26][CH2:27][CH2:28][CH3:29]>>[NH2:22][C:23](=[O:32])[CH:24]([OH:31])[CH:25]([NH:30][C:14](=[O:16])[C:13]1[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=1[C:10]1[N:11]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[S:8][CH:9]=1)[CH2:26][CH2:27][CH2:28][CH3:29]

Participants

3

Reactant 2

HCID 27668822-(2-Phenyl-1,3-thiazol-4-yl)benzoic acidHCID 11790139HCID 11790139, compound

Product 1

HCID 67540821HCID 67540821, compoundYield 87.7%

Procedure

Coupling of 2-(2-phenylthiazol-4-yl)benzoic acid (200 mg, 0.711 mmol) and 1-amino-2-hydroxy-1-oxoheptan-3-aminium chloride (145 mg, 0.737 mmol) in an analogous manner as described for example 1.2 afforded 264 mg of the title compound as white solid.

Sources & evidence

ORD record
ord-93af8f80e1dd414c8f2bc4559fa1e01d
Source dataset
uspto-grants-2014_12
Patent number
US08906941B2

Reaction notes

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