Sodium Hydroxide → 2-(2-Phenyloxazol-4-yl)nicotinic acid

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Reaction Steps

An aqueous solution of NaOH (0.27 mL, 2M in water, 0.54 mmol) was added to a solution of ethyl 2-(2-phenyloxazol-4-yl)nicotinate (80 mg, 0.27 mmol) in EtOH (2.7 mL). After stirring overnight at room temperature the solvent was removed in vacuo, the residue was dissolved in water and HCl (2M in water) was added until pH ˜1 was obtained. The solvent was removed in vacuo and the crude product obtained was used without further purification; ESI-MS [M+H+]=267.1.

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