HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1400323Generated: November 1, 2026
4-Methylphenylhydrazine monohydrochloride → 2-ethyl-8-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
https://huagongshe.com/reaction/1400323
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Methylphenylhydrazine monohydrochloride | HCID 12504 | — |
| Reactant | 1-Ethylpiperidin-4-one--hydrogen chloride (1/1) | HCID 12319915 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-ethyl-8-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole | HCID 59455066 | — |
Reaction Steps
To a solution of p-tolylhydrazine hydrochloride (1 equiv.) in EtOH is added 1-ethylpiperidin-4-one hydrochloride (0.76-1.4 equiv.) and the contents are heated at 80° C. for 16 h. After completion of the reaction, as monitored by LCMS, the reaction mixture is concentrated to dryness and basified with aq. saturated NaHCO3. The reaction product is extracted with EtOAc and the organic layer is separated, dried over sodium sulfate and concentrated to obtain 2-ethyl-8-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08906925B2 |
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| Source dataset | uspto-grants-2014_12 |
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| ORD ID | ord-5957e0f2f93543ceaf0dcb91047ace93 |
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| Source note | uspto-grants-2014_12 |
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