Sodium Hydroxide → HCID 73386948, compound

Participants

Reaction Conditions

Reaction Steps

A solution of methyl (2S)-2-(tert-butoxy)-2-{31-fluoro-4-methyl-29-oxa-5,7,8,26-tetraazaheptacyclo[24.6.2.16,9.110,14.02,7.015,20.030,34]hexatriaconta-1(32),2,4,6(36),8,10(35),11,13,15(20),16,18,30,33-tridecaen-3-yl}acetate (0.063 g, 0.097 mmol) in MeOH (2 mL) was treated with NaOH (0.24 mL, 0.48 mmol) and the reaction was heated (70° C. oil bath) for 2.5 hrs. The reaction was cooled and then purified by prep-HPLC to afford the desired product (0.0278 g, 0.044 mmol, 45.2% yield). LCMS (M+H)=635.5.

Provenance & Evidence