Reaction Steps
A mixture of example 20 (30 mg, 0.050 mmol), 10% Pd/C (5.35 mg, 5.03 μmol) in MeOH was stirred under a H2 balloon for 3 h. It was then filtered and concentrated to obtain 28 mg (93%) of the desired product as a white solid. 1H NMR (500 MHz, CDCl3) δ 8.51 (br. s., 1H), 7.70 (d, J=7.1 Hz, 1H), 7.54 (t, J=7.6 Hz, 1H), 7.47 (d, J=7.3 Hz, 1H), 7.40 (d, J=6.6 Hz, 1H), 7.34 (t, J=7.2 Hz, 1H), 7.04 (d, J=7.1 Hz, 2H), 6.81 (s, 1H), 6.01 (br. s., 1H), 4.59 (t, J=11.9 Hz, 1H), 4.13 (br. s., 2H), 3.91 (t, J=11.5 Hz, 1H), 3.53 (d, J=3.5 Hz, 1H), 3.42 (d, J=4.9 Hz, 2H), 2.84 (d, J=9.9 Hz, 1H), 2.63 (br. s., 3H), 2.36 (br. s., 1H), 2.16 (br. s., 1H), 2.10-2.02 (m, 1H), 1.93 (d, J=12.5 Hz, 1H), 1.80 (d, J=9.0 Hz, 2H), 1.70-1.54 (m, 2H), 1.36-1.20 (m, 12H). LCMS (M+1)=599.38.
