HCID 86710795, compound → HCID 86710794, compound

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A mixture of methyl (2S)-2-(tert-butoxy)-2-[(22S,24Z)-4,22,28-trimethyl-17-(trifluoromethyl)-21,27-dioxa-1,5,7,8-tetraazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18,24-undecaen-3-yl]acetate (50 mg, 0.071 mmol), 10% Pd/C (7.53 mg, 7.07 μmol) in MeOH (2 mL) was stirred under a H2 balloon for 2 h. It was then filtered, concentrated and purified by biotage eluting with 20% EtOAc/hexane to isolate 38 mg of methyl (2S)-2-(tert-butoxy)-2-[(22S)-4,22,28-trimethyl-17-(trifluoromethyl)-21,27-dioxa-1,5,7,8-tetraazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate as an off-white solid. LCMS (M+1)=709.3.

Provenance & Evidence